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The pathology of Plasmodium chabaudi infection is not ameliorated by the secreted filarial nematode immunomodulatory molecule, ES‐62
Author(s) -
LAMB T. J.,
VOISINE C.,
KOERNIG S.,
EGAN C. A.,
HARNETT W.,
LANGHORNE J.
Publication year - 2007
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.2007.00941.x
Subject(s) - plasmodium chabaudi , immune system , immunology , malaria , biology , inflammation , phosphorylcholine , rheumatoid arthritis , immunity , plasmodium falciparum , parasitemia , biochemistry
SUMMARY ES‐62 is a phosphorylcholine‐containing glycoprotein secreted by filarial nematodes. This molecule has been shown to reduce the severity of inflammation in collagen‐induced arthritis (CIA) in mice, a model of rheumatoid arthritis, via down‐regulation of anti‐collagen type 1 immune responses. Malaria parasites induce a pro‐inflammatory host immune response and many of the symptoms of malaria are immune system‐mediated. Therefore we have asked whether the immunomodulatory properties of ES‐62 can down‐regulate the severity of malaria infection in BALB/c mice infected with Plasmodium chabaudi. We have found that ES‐62 has no significant effect on the course of P. chabaudi parasitaemia, and does not significantly affect any of the measures of malaria‐induced pathology taken throughout infection .