Premium
Trypanosoma congolense infections: MHC class II‐restricted immune responses mediate either protection or disease, depending on IL‐10 function
Author(s) -
SHI M. Q.,
WEI G. J.,
TABEL H.
Publication year - 2007
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.2006.00925.x
Subject(s) - biology , immunology , immune system , major histocompatibility complex , mhc class ii , trypanosoma , mhc class i , cd1 , t cell , virology , il 2 receptor
SUMMARY BALB/c mice are highly susceptible and C57BL/6 relatively resistant to Trypanosoma congolense infections. Here we show that relatively resistant wild‐type B6 mice infected with T. congolense survive significantly longer (> 200 days) than infected major histocompatibility complex (MHC) class II‐deficient B6 mice (∼50 days). We also show that blocking of the interleukin‐10 (IL‐10) receptor induces early death of wild‐type B6 mice infected with T. congolense (∼10 days), but does not affect the survival of infected MHC class II‐deficient B6 mice. We conclude that MHC class II‐restricted immune responses mediate protection and, when IL‐10 function is impaired, MHC class II‐restricted immune responses mediate early mortality in otherwise resistant B6 mice. Thus, in T. congolense infections, MHC class II‐restricted immune responses mediate either protection or disease, depending on IL‐10 function.