Premium
ES‐62 is unable to modulate Toxoplasma gondii ‐driven Th1 responses and pathology
Author(s) -
Couper K. N.,
Chen W.,
Houston K. M.,
Harnett W.,
Johnson L. L.
Publication year - 2005
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.2005.00755.x
Subject(s) - toxoplasma gondii , biology , immunology , toxoplasmosis , nematode , immunopathology , nematode infection , helminthiasis , antibody , ecology
SUMMARY ES‐62, a filarial nematode‐derived anti‐inflammatory immunomodulator, was administered to mice in an attempt to prevent pathology associated with Toxoplasma gondii infection. The nematode product was shown to elevate mitogen and T. gondii ‐specific IL‐10 production but was unable to inhibit Th1 responses. Consequently ES‐62 could not prevent Th1 generated immunopathology.