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Identification of CD4 + T cell epitopes of Taenia solium paramyosin
Author(s) -
LópezMoreno H. S.,
Correa D.,
Laclette J. P.,
OrtizNavarrete V. F.
Publication year - 2003
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.2003.00658.x
Subject(s) - epitope , taenia solium , biology , immune system , immunodominance , immunization , t cell , virology , peptide sequence , cysticercosis , immunology , antigen , microbiology and biotechnology , biochemistry , gene , zoology
T cell mediated response is involved in a protective immune response against experimental cysticercosis conferred by immunization with Taenia solium paramyosin (TPmy) to BALB/c mice. In this study, we analysed the TPmy amino acid sequence for predicted CD4 + T cells epitopes. Five different regions of this protein showed that the residues anchor to bind the I‐A d molecule; synthetic peptides containing these epitopes were evaluated for their ability to induce lymphoproliferative responses of spleen cells from TPmy immunized mice. Among them, Tp176 (amino acids 176–192 sequence DDLQRQMADANSAKSRL) was the immunodominant T cell epitope of TPmy. Delineation of this epitope should facilitate analysis of the role of CD4 + T cell response in experimental cysticercosis.