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Genetic control of immunity to Heligmosomoides polygyrus : fixed H‐2 E positive but not H‐2 negative cells can present antigen to a parasite‐specific T cell hybridoma
Author(s) -
ROBINSON MICHAEL,
GUSTAD THOMAS R.,
GARNER STEPHANIE D.,
DAVID CHELLA S.
Publication year - 1995
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1995.tb01021.x
Subject(s) - heligmosomoides polygyrus , biology , antigen , context (archaeology) , immunology , antigen presentation , major histocompatibility complex , t cell , t lymphocyte , antigen processing , antigen presenting cell , immune system , mhc class i , paleontology
SUMMARY A number of T cell hybridomas were produced to adult worm homogenate (AWH) antigen of the nematode parasite Heligmosomoides polygyrus. All of the hybridomas were of the H‐2 d haplotype and could potentially accept antigen in the context of either the A d or E d , H‐2 molecules. Three types of antigen presentation were observed, with some of the T cell hybridomas accepting antigen in the context of the E and some in the context of the A molecule. A third type of hybridoma responded to antigen presented by paraformaldehyde fixed APC, but only when APCs were Epositive. These same hybridomas, were however, stimulated by A WH, when the antigen was presented by syngeneic but unfixed, E positive or E negative A PC. Therefore these data indicate that certain H. polygyrus‐specfic T cell hybridomas can accept parasite antigen when presented in the context of either the H‐2 A or E molecule, but the presentation of antigen by the two different MHC Class II molecules, can apparently utilize differing processing mechanisms.,