Premium
Immunity to a challenge infection of Strongyloides stercoralis third‐stage larvae in the jird
Author(s) -
NOLAN THOMAS J.,
ROTMAN HARRIS L.,
BHOPALE VEENA M.,
SCHAD GERHARD A.,
ABRAHAM DAVID
Publication year - 1995
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1995.tb01004.x
Subject(s) - strongyloides stercoralis , biology , immune system , immunology , immunity , strongyloidiasis , larva , helminths , botany
SUMMARY Jirds support the entire life‐cycle of Strongyloides stercoralis. We therefore used this host as a model to define the mechanism of the immune response to a challenge infection, as well as the parasite stage effected by the response. Jirds given a primary infection of S. stercoralis are resistant to re‐infection. The use of implanted diffusion chambers containing larvae showed that the immune response killed the third‐stage larvae, and this was confirmed by subcutaneous infections. The larvae of a challenge infection are killed within 48 h, a time period too short to allow for the development of L4 and adult worms. The immune response is dependent on both a serum factor and cells, suggestive of an ADCC type response.