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NK and LAK functions in human chronic Chagas disease
Author(s) -
STRACIERI A.B.P.L.,
VOLTARELLI J.C.
Publication year - 1995
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1995.tb00905.x
Subject(s) - lymphokine activated killer cell , immunology , chagas disease , asymptomatic , k562 cells , immunosuppression , biology , disease , natural killer cell , medicine , immune system , cd8 , cytotoxicity , in vitro , interleukin 21 , biochemistry , leukemia
Summary Natural killer (NK) and lymphokine activated killer (LAK) functions were measured in 40 patients with chronic Chagas disease divided into asymptomatic/indeterminate (18) and symptomatic forms (22) and in 24 healthy controls. A chromium release assay was used employing K562 or P815 cell lines as targets. There was no difference in either NK or LAK activity between the three groups. A small number of patients in each group showed results above or below the normal range for controls. However, there was no correlation between NK and LAK values in the same individual. In conclusion, NK and LAK functions do not seem to be involved in the immunosuppression associated with human chronic Chagas disease.