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The effects of H2 and non‐H2 genes on the survival of Onchocerca lienalis microfilariae in the mouse
Author(s) -
FOLKARD SHELLEY G.,
BIANCO ALBERT E.
Publication year - 1995
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1995.tb00899.x
Subject(s) - biology , congenic , gene , parasite hosting , onchocerca , immunity , immunology , virology , immune system , genetics , onchocerciasis , onchocerca volvulus , world wide web , computer science
Summary The effect of H2 and non‐H2 genes in a mouse model of protective immunity against Onchocerca lienalis microfilariae have been investigated. Non‐H2 effects were determined using CBA, BALB/c, B10, SJL and TO strains. All were permissive for establishment of a primary infection with microfilariae, although significant differences in parasite recoveries were evident amongst the various strains. The effect of H2 genes upon a primary infection was investigated using H2 congenic B10 and BALB strains, B10, B10.S, B10.BR, B10.D2/n, BALB/c, BALB.B, and BALB.K. Significant H2 effects were seen among the relatively weak responder B10 strains, but were not present among the relatively strong responder BALB strains. These results support a dominant effect of non‐H2 genes following primary exposure to microfilariae, and a ‘fine tuning’ effect of H2 genes that is apparent only in weaker responding strains. Upon reinfection of all the strains investigated, a gradation of protection was detected that appeared to be exclusively dependent upon H2.,