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Complex formation of human alpha‐1–antitrypsin with components in Schistosoma mansoni cercariae
Author(s) -
MODHA JAY,
DOENHOFF MICHAEL J.
Publication year - 1994
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1994.tb00372.x
Subject(s) - schistosoma mansoni , biology , schistosomiasis , elastase , immunoelectrophoresis , immunology , blot , alpha (finance) , antigen , helminths , biochemistry , enzyme , medicine , construct validity , nursing , patient satisfaction , gene
SUMMARY Human alpha‐1–antitrypsin (α 1 ‐AT) was incubated with an extract of Schistosoma mansoni cercariae or porcine pancreatic elastase and analysed by immunoelectrophoresis and Western blotting. The inhibitor was shown to form complexes with components in S. mansoni cercariae in the same way as elastase. The role of α 1 ‐AT in S. mansoni infection is discussed.