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Selective effector mechanisms for the expulsion of intestinal helminths
Author(s) -
NAWA YUKIFUMI,
ISHIKAWA NAOTO,
TSUCHIYA KIMIYUKI,
HORII YOICHIRO,
ABE TATSUYA,
KHAN AZHARUL I.,
SHI BING,
ITOH HIROSHI,
IDE HISAMITSU,
UCHIYAMA FUKUMI
Publication year - 1994
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1994.tb00358.x
Subject(s) - effector , biology , immunology , host (biology) , in vivo , helminths , microbiology and biotechnology , ecology , genetics
SUMMARY In the middle of the era of molecular biology, much less attention is paid to in vivo phenomena. However, carefully designed experimental systems in vivo still can provide valuable information as to the mechanisms underlying the establishment and maintenance of host‐parasite relationships. In this review we describe the advantage of using concurrent infections with appropriately chosen combinations of different genera or different maturation stages of parasites to segregate the cellular responses of the host. By means of simple experimental approaches we have found that mucosal mast cells and goblet cells, both of which have long been considered as non‐specific effectors, are in fact highly selective and specific effector cells of the host defence mechanisms capable of acting on the establishment and the expulsion of intestinal helminths.