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Cross‐protection between species of the Schistosoma haematobium group induced by vaccination with irradiated parasites
Author(s) -
NAVARRETE S.,
ROLLINSON D.,
AGNEW A. M.
Publication year - 1994
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1994.tb00300.x
Subject(s) - biology , schistosoma haematobium , vaccination , schistosoma , schistosomiasis , immunology , helminthiasis , trematoda , helminths , schistosoma mansoni , virology , zoology
SUMMARY Mice vaccinated with irradiated cercariae of Schistosoma haematobium, S. bovis and S. margrebowiei showed good levels of resistance (38–62%) against an homologous challenge, and varying degrees of resistance (19–46%), against challenges with closely related species. No protection against S. mansoni was induced by vaccination with any of these species. This restricted cross‐protection reflects the close phylogenetic relationship between species of the S. haematobium group and indicates that immunologically important epitopes are conserved within this species complex.