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Soluble (s)CD23 levels in a parasitized population from Papua New Guinea
Author(s) -
PRITCHARD D. I.,
KUMAR SANJEEV,
EDMONDS P.
Publication year - 1993
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1993.tb00601.x
Subject(s) - new guinea , biology , immunology , population , cd23 , zoology , immunoglobulin e , environmental health , antibody , medicine , ethnology , history
Summary Levels of sCD23, total and specific IgE were found to be considerably elevated in the plasma of a helminth infected population from Papua New Guinea. Using age‐corrected data, a significant negative correlation was seen between sCD23 and total IgE in the young, at a time when hookworms are being rapidly acquired, and total IgE levels are rising most dramatically. It is suggested on the basis of this data that this inverse correlation is due to the stabilizing effect of IgE on the FceRII receptor in vivo, and that the high levels of sCD23 seen in hookworm infected individuals are partly responsible for the high levels of IgE recorded in these patients.