Premium
Vaccination of dogs against Babesia canis infection using parasite antigens from in vitro culture
Author(s) -
SCHETTERS TH. P. M.,
KLEUSKENS J.,
SCHOLTES N.,
BOS H. J.
Publication year - 1992
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1992.tb00469.x
Subject(s) - parasite hosting , babesia canis , biology , antigen , vaccination , babesia , babesiosis , immunology , virology , canis , in vitro , adjuvant , antibody , microbiology and biotechnology , paleontology , biochemistry , world wide web , computer science
Summary Groups of five dogs were vaccinated with different Babesia canis vaccine formulations. It appeared that partial protection against challenge infection was obtained when using parasite antigens from in vitro culture in combination with saponin. Protection was evident as a decrease in parasitaemia after challenge and was associated with the presence of serum antibodies against Babesia parasites. In addition, parasite antigen derived from in vitro culture supernatant exhibited more protective activity than somatic parasite antigen, in that a less marked fall of haematocrit values was found after challenge infection. The fall of haematocrit value observed in the animals immunized with somatic parasite antigen was not different from that observed in the adjuvant control group.