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T lymphocyte dependent enteropathy in murine Trichinella spiralis infection
Author(s) -
GARSIDE P.,
GRENCIS R. K.,
MOWAT A. McI.
Publication year - 1992
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1992.tb00462.x
Subject(s) - trichinella spiralis , biology , enteropathy , immunology , hyperplasia , atrophy , crypt , lymphocyte , villous atrophy , trichinella , pathology , helminths , medicine , endocrinology , disease , coeliac disease , genetics
Summary Mice infected with Trichinella spiralis developed significant enteropathy, comprising villus atrophy, crypt hyperplasia, goblet cell hyperplasia and a decrease in intra‐epithelial lymphocyte numbers by 10 days post‐infection, when most of the parasites had been expelled from the gut. However, worm expulsion was prevented by treatment with cyclosporin A and, despite a continued parasite burden, cyclosporin A treated animals had no villus atrophy or changes in inflammatory cell numbers. These results confirm that the expulsion of T. spiralis from the mouse gut is accompanied by a significant intestinal lesion and that both of these phenomena are T‐cell mediated.