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Immune response of Clun Forest sheep to vaccination with membrane glycoproteins from Haemonchus contortus
Author(s) -
TAVERNOR ANGELA S.,
SMITH TREVOR S.,
LANGFORD CORDELIA F.,
GRAHAM MARGARET,
MUNN EDWARD A.
Publication year - 1992
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1992.tb00038.x
Subject(s) - haemonchus contortus , biology , immune system , vaccination , immunology , glycoprotein , helminths , microbiology and biotechnology
Summary Clun Forest lambs were injected with a fraction containing integral membrane glycoproteins derived from the intestinal microvilli of Haemonchus contortus in two equal doses of 0.5, 5, 50 or 500 μg protein and then challenged with 10 000 infective larvae. The time‐course of serum specific antibody responses were determined. Compared to the adjuvant control group, the animals injected with 1000 μg protein were better than 84% protected and those injected with 100 μg. better than 95% protected by all criteria. For these two groups parasite egg output was reduced 99% on average over the patent period. Two of the animals injected with 10 μg protein were partially protected, with 86% reduction in egg output. Two animals in the group injected with 1 μg protein also showed partial protection. Antibody level correlated with protection.