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Vaccination of young Dorset lambs against haemonchosis
Author(s) -
TAVERNOR ANGELA S.,
SMITH TREVOR S.,
LANGFORD CORDELIA F.,
MUNN EDWARD A.,
GRAHAM MARGARET
Publication year - 1992
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1992.tb00036.x
Subject(s) - biology , vaccination , haemonchus contortus , parasite hosting , antibody , immunology , helminths , veterinary medicine , physiology , medicine , world wide web , computer science
Summary Six Dorset Horn lambs were each vaccinated at age 7 weeks and 9 weeks with 50 μg of glycosylated integral membrane proteins, particularly enriched in the protein H11 from the intestinal brush border of adult Haemonchus . At 11 weeks of age the lambs were infected with 10 000 infective third stage Haemonchus larvae. Compared with the average for the control group the vaccinated group of lambs had a 78% reduction in parasite egg output over the patent period, with four of the six better than 93% protected. At autopsy 35 days post‐infection the mean total worm burden of the vaccinated lambs was 83% reduced compared with the controls. The serum antibody titres to H11 correlated with the degree of protection.