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A specific T‐cell receptor genotype preference in the immune response to a synthetic Plasmodium falciparum malaria vaccine
Author(s) -
MURILLO LUIS A.,
TENJO FERNANDO A.,
CLAVIJO OLGA P.,
OROZCO MAURICIO A.,
SAMPAIO SILVIA,
KALIL JORGE,
PATARROYO MANUEL E.
Publication year - 1992
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1992.tb00008.x
Subject(s) - biology , malaria , immunology , plasmodium falciparum , malaria vaccine , genotype , immune system , antibody , virology , polymerase chain reaction , gene , genetics
Summary In recent studies with 63 and 122 volunteers vaccinated with the SPf 66 synthetic malaria vaccine, specific antibody patterns were classified as high or low responders. Using the Polymerase Chain Reaction (PCR), a specific and selective preference was shown for the Vβ arrangement of the T‐cell receptor in the high responder group involving the Vβ‐8 gene. The low responder group showed the rearrangement of a different set of genes, and a particular association with Vβ‐10.