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Variations in susceptibility to Leishmania amazonensis infection in lines of mice selected for high or low immunoresponsiveness
Author(s) -
FALCOFF R.,
BARRALNETTO M.,
STIFFEL C.,
BOUTHILLIER Y.,
BARRAL A.,
FREITAS L.A.,
MEVEL J.C.,
MOUTON D.
Publication year - 1991
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1991.tb00559.x
Subject(s) - biology , immune system , leishmania , phenotype , immunology , leishmania major , leishmania mexicana , antibody , leishmaniasis , parasite hosting , genetics , gene , world wide web , computer science
Summary The degree of resistance to a local Leishmania amazonensis challenge has been compared in lines of mice obtained by selective breeding for high or low immunoresponsheness: High and Low antibody responder mice of Selections I and II (H 1 , H 11 and L 1 L 11 lines) and high and low responder mice to T mitogen PHA (Hi/PHA and Lo/PHA). The aim of this preliminary study was to focus attention on genetic differences related with well defined immune characteristics. Clear‐cut results were obtained, both H 1 and H 11 mice developed large and disseminating lesions, the rale of symptom aggravation being faster in H 11 , while L 1 and LM proved resistant to parasites, only small and transient lesions being observed for them during a 150 days follow up. The outcome of infection also differs in Hi/PHA and Lo/PHA mice, Hi/PHA having a resistant and Lo/PHA a susceptible phenotype.