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Schistosoma mansoni: immuno‐localization of the calcium binding protein Sm20
Author(s) -
HAVERCROFT J.C.,
SMITH A.L.,
WILLIAMS R.H.
Publication year - 1991
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1991.tb00555.x
Subject(s) - viral tegument , schistosoma mansoni , biology , calcium binding protein , calcium , microbiology and biotechnology , antiserum , contraction (grammar) , trematoda , immunology , helminths , schistosomiasis , anatomy , antibody , endocrinology , medicine , virology
Summary The 20 kDa calcium binding protein of Schistosoma mansoni , Sm20. is expressed in all stages of the life cycle from the cercaria to the adult worm and in the egg, with equal levels of Sm20 present in adult male and female worms. Localization of Sm20 by immuno‐electron microscopy using Sm20‐specjric antisera and the protein A gold technique demonstrated that the majority of Sm20 is expressed in muscle but that it may also be expressed at low levels in the tegument. These results suggest that Sm20 plays a role in the calcium mediated regulation of muscle contraction. However, it is not clear whether Sm20 acts as a reservoir for calcium in muscle or is directly involved in the regulatory mechanisms of contraction.