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Genetic studies on a major merozoite surface antigen of the malaria parasite of rodents, Plasmodium chabaudi
Author(s) -
McLEAN ANN P.,
LAINSON F.ALEXANDER,
MSHARKEY ANDREW,
WALLKER DAVID
Publication year - 1991
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1991.tb00290.x
Subject(s) - plasmodium chabaudi , biology , antigen , monoclonal antibody , virology , immunofluorescence , merozoite surface protein , gene , malaria , parasite hosting , allele , immunology , antibody , genetics , plasmodium falciparum , malaria vaccine , parasitemia , world wide web , computer science
Summary Diversity in a major merozoite surface antigen (MSA‐1) of plasmodium chabaudi has been examined using a panel of monochlonal antibodies (MoAbs). The antigen was found to be different in each of twelve cloned isolates, as shown by its reactivity with the MoAbs in immunofluorescence tests. In genetic crossing experiments, the diverse forms of this antigen were shown to be determine by allelic variation of a single gene. Recombination occurred between the MSA‐1 gene, a second blood stage antigen and enzyme markers.