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Inhibitory activity of IL‐6 on malaria hepatic stages
Author(s) -
PIED SYLVIANE,
RENIA LAURENT,
NUSSLER ANDREAS,
MILTGEN FRANÇOIS,
MAZIER DOMINIQUE
Publication year - 1991
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1991.tb00276.x
Subject(s) - plasmodium yoelii , catalase , superoxide dismutase , biology , superoxide , malaria , hydrogen peroxide , parasite hosting , immunology , plasmodium falciparum , parasitemia , enzyme , biochemistry , world wide web , computer science
Summary Addition of recombinant inlcrleukin‐6 (IL‐6) to Plasmodium yoelii hepatic cultures resulted in a specific dose‐dependent inhibition of parasite development. Time course experiments showed that, without any direct effect on free sporozoites, IL‐6 exerts its action during both the early phase of infection and during the subsequent maturation of the schizonts. Elicitation of the oxidative burst appears lo be one mechanism by which IL‐6 interferes with the development of hepatic phase. Catalase and superoxide dismutase, two scavengers of hydrogen peroxide and superoxide anions, reversed the IL‐6 mediated parasiticidal activity.