Premium
Characterization of the thoracic duct T‐helper cells that co‐mediate, with antibody, the rapid expulsion of Trichinella spiralis in adult rats
Author(s) -
AHMAD A,
BELL R.G.,
WANG C.H.,
SACUTO F.R.
Publication year - 1991
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1991.tb00271.x
Subject(s) - biology , trichinella spiralis , immunology , antibody , trichinosis , thoracic duct , duct (anatomy) , helminths , anatomy , lymphatic system
Summary Thoracic duct cells that act synergistically with immune serum or antibody to transfer rapid expulsion of a challenge infection with Trichinella spiralis muscle larvae were characterized as OX38 + , OX8 − ,OX22 − T helper cells. Protective capacity was confined to the dividing T helpers that appeared on days 3–5 in the thoracic duct of rats during a T. spiralis infection. To realize their intestinal priming potential in recipient rats, MHC‐compatibility between donor and recipient rat was required. Fractionation of immune serum with 40% saturated ammonium sulphate left transferable protective activity in both the precipitate and supernatant fractions. Absorption of immune serum with muscle larvae antigen removed the capacity to transfer protection.