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Characterization of a polymorphic immunodominant molecule in sporozoites and schizonts of Theileria parva
Author(s) -
TOYE P.G.,
GODDEERIS B.M.,
IAMS K.,
MUSOKE A.J.,
MORRISON W.I.
Publication year - 1991
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1991.tb00262.x
Subject(s) - biology , theileria parva , antigen , virology , epitope , monoclonal antibody , western blot , immunodominance , antibody , parasite hosting , antiserum , theileria , blot , immune system , microbiology and biotechnology , apicomplexa , protozoa , immunology , genetics , gene , plasmodium falciparum , malaria , world wide web , computer science
Summary This study examines several aspects of a polymorphic, immunodominant molecule (P!M) found in the protozoan parasite. Theileria parva. The antigen is present in all T. p. parva stocks examined, and in the related subspecies, T. p. bovis and T. p. lawrencei. It is the predominant antigen recognized by antisera from immune cattle on Western blot analysis of schizont‐infected lymphocytes, and is the only antigen which has been shown to react with anti‐schizont monoclonal antibodies (MoAbs) on Western blots or in immunoprecipitations. The antigen shows polymorphism in both size and expression of antibody epitopes among the different stocks of T. parva. The antigen is present in sporozoites as well as schizonts.