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Oxygen derived free radicals and the course of Eimeria vermiformis infection in inbred strains of mice
Author(s) -
OVINGTON K.S.,
SMITH N.C.,
JOYSEY H. S.
Publication year - 1990
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1990.tb00992.x
Subject(s) - biology , inbred strain , immunology , immunity , eimeria , microbiology and biotechnology , immune system , genetics , gene
Summary Free radical generation by peritoneal leukocytes from BALB/c and C57BL/6 mice was monitored for 18 days following infection with Eimeria vermiformis. Free radical generation occurred earlier and was quantitatively much greater in resistant BALB/c mice than in susceptible C57BL/6 mice, resistance being indicated by a much lower oocyst production and a shorter patent period of E. vermiformis. Plasma greatly enhanced free radical generation in response to a soluble antigen prepared from sporulated oocysts indicating the presence of plasma‐borne factor(s) which enhance free radical generation in response to E. vermiformis.