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Injection of microfilariae induces resistance to Brugia malayi infection in ferrets and accelerates development of lymphostatic disease
Author(s) -
CRANDALL R.B.,
CRANDALL CATHERINE A.,
NAYAR J.K.
Publication year - 1990
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1990.tb00950.x
Subject(s) - brugia malayi , lymphatic filariasis , lymphatic system , biology , immunology , immune system , antigen , parasite hosting , disease , helminthiasis , helminths , filariasis , pathology , medicine , world wide web , computer science
Summary Ferrets injected intravenously with living microfilariae or cutaneously with microfilariae followed by intravenous injection developed partial resistance to a challenge infection as measured by recovery of adult filariae from lymphatics. Following a challenge infection, the ferrets injected with microfilariae developed lymphatic pathology characteristic of a chronic infection or that observed following multiple infections. There was disruption of lymphatic drainage of the infected limb and lymphoedema. The results suggest that immune responses to antigens of microfilariae, presumably antigens shared with other developmental stages, effected both increased resistance and enhanced lymphatic pathology.