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Genetic control of immune response to a purified Schistosoma mansoni antigen. I. Effect of MHC class II antigens on the cellular, humoral and protective responses
Author(s) -
MENDLOVIC F.,
TARRAB–HAZDAI R.,
PURI J.,
AR R.
Publication year - 1989
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1989.tb00928.x
Subject(s) - antigen , schistosoma mansoni , biology , immune system , immunology , major histocompatibility complex , congenic , schistosomiasis , genetics , gene , helminths
Summary The influence of the I region of the major histocompatibility complex (MHC) on T–dependent immune responses against a purified schistosome antigen (9B antigen) was investigated. H–2 congenic mice expressing both I–A and I–E antigens (I–E + ) showed a higher in–vitro proliferation to 9B antigen as compared to the recombinant strains expressing only I–A (I–E – ). These two strains of mice differed both qualitatively and quantitatively in the humoral responses elicited by the purified antigen. Furthermore, in–vivo protection experiments showed that mice which do not express I–E molecules can be partially protected against the disease by prior immunization with the 9B antigen in contrast to their I–E expressing counterparts. The possible role of the I–E molecule in the immune responses elicited during Schistosoma mansoni infection is discussed.