Premium
Vaccination trial against canine visceral leishmaniasis
Author(s) -
DUNAN S.,
FROMMEL D.,
MONJOUR L.,
OGUNKOLADE B. W.,
CRUZ A.,
QUILICI M.
Publication year - 1989
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1989.tb00676.x
Subject(s) - visceral leishmaniasis , leishmania infantum , immunization , biology , vaccination , leishmaniasis , leishmania , adjuvant , canine leishmaniasis , immunology , leishmania donovani , virology , antigen , parasite hosting , world wide web , computer science
Summary n a double‐blind study 393 seronegative dogs, residing in a holoende‐mic area for Leishmania donovani infantum infection, were randomly assigned to an immunization with a partly purified L.d. infantum‐derived preparation, or received adjuvant only. During the first year of the study period the rate of infection was significantly higher in the vaccinated group than in the control one ( P < 005), but this difference disappeared during the second year ( P = 0–44). Since a similar immunization protocol conferred resistance against experimental murine leishmaniasis, these results stress the differences that may exist between the natural hosts of Leishmania parasites and experimental animal substitutes.