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The effect of MHC compatibility between parasite–infected cell line and recipient in immunization against tropical theileriosis
Author(s) -
INNES E. A.,
OUHELLI H.,
OLIVER R. A.,
SIMPSON S. P.,
BROWN C. G. D.,
SPOONER R. L.
Publication year - 1989
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1989.tb00647.x
Subject(s) - biology , immunology , immune system , major histocompatibility complex , priming (agriculture) , theileria parva , immunization , t cell , virology , parasite hosting , cell culture , genetics , botany , germination , world wide web , computer science
Summary Lymphoblastoid cell lines, infected and transformed in vitro by a Moroccan stock of Theileria annulata , infected and immunized susceptible taurine cattle, at cell doses of 10 8 , 10 6 , 10 4 and 10 2 , regardless of whether the recipients were Bo LA matched or mismatched to the donor cell line. The MHC relationship between the cell line and recipient did affect the severity of the clinical response to cell line immunization which may reflect differences in the specific priming of the immune response. At the highest cell doses the BoLA–mismatched recipients reacted more severely than the BoLA–matched. This study shows that, unlike the closely related parasite T. parva , there is no histocompatibility barrier to immunization using T. annulata–infected cell lines which could be achieved with as few as 10 2 allogeneic infected cells. The role of MHC compatibility between cell line and recipient in the priming of a protective immune response is discussed.