Premium
In‐vivo encapsulation and killing of Litomosoides carinii in white rats
Author(s) -
OGBOGU V.C.,
STOREY D.M.
Publication year - 1988
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1988.tb00216.x
Subject(s) - biology , parasite hosting , ultrastructure , immunology , in vivo , capsule , phagocytosis , microbiology and biotechnology , anatomy , botany , world wide web , computer science
Summary Ultrastructural studies revealed that in albino rats Litomosoides carinii was encapsulated and eventually killed in the pleural cavity by adherent host cells. Encapsulation was an organized cellular reaction which sequestered and eventually degraded the parasites. The process evolved in three phases: primary accumulation of host cells, especially eosinophils and macrophages, around the parasites with concentration of eosinophils on the parasite surface; secondary transformation of macrophages into epithclioid cells which replaced eosinophils on the parasite surface; finally, dead parasites became calcified and were gradually degraded within a tough, compacted fibrotic capsule.