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Anti‐gamete antibodies block transmission of human vivax malaria to mosquitoes
Author(s) -
MUNESINGHE YAMUNA D.,
MENDIS KAMINI N.,
CARTER RICHARD
Publication year - 1986
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1986.tb01035.x
Subject(s) - biology , plasmodium vivax , malaria , virology , vivax malaria , immunology , antibody , gamete , transmission (telecommunications) , plasmodium falciparum , genetics , engineering , sperm , electrical engineering
Summary Antibodies were raised in rabbits by immunizing against fresh unfixed or cryopreserved female gametes of the human malaria pathogen Plasmodium vivax. The antibodies were shown to react with the surface of gametes by the indirect immunofluorescent test. When parasite isolates from P. vivax infected individuals were fed through a membrane to Anopheles tessellatus mosquitoes in the presence of immune rabbit sera, they completely blocked the infectivity of the parasite isolates to the vector. Immunoglobulins separated from these sera also blocked infectivity to the same extent as did the immune sera indicating that antibodies were responsible for the transmission blocking effect of the sera. This study indicated that P. vivax like other malaria parasites is highly susceptible to anti gamete transmission blocking immunity.