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Genetic control of immunity to Trichinella spiralis in mice. Response of rapid‐ and slow‐responder strains to immunization with parasite antigens
Author(s) -
WAKELIN D.,
MITCHELL L. A.,
DONACHIE A. M.,
GRENCIS R. K.
Publication year - 1986
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1986.tb00842.x
Subject(s) - trichinella spiralis , immunization , biology , immunology , antigen , immunity , trichinella , trichinosis , immune system , virology , helminths
Summary Slow‐responder C57BL/10 (BIO) mice responded poorly to immunization with muscle larval antigen of Trichinella spiralis showing no accelerated loss of worms from a subsequent challenge infection. In contrast, rapid‐responder NIH mice and (BlOxNIH) F, mice developed high levels of immunity after immunization. Lymphocyte proliferation studies showed that immunized BIO mice did respond to in vitro restimulation with antigen, though less well than NIH mice. Failure of B10 mice to respond to immunization did not therefore reflect a failure to recognize larval antigen, a view confirmed by the fact that immunization was achieved using abbreviated enteral infections and, to a smaller extent, by parenterally administered muscle larvae.