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The role of the macrophage in immunity to Trypanosoma musculi
Author(s) -
FERRANTE A.
Publication year - 1986
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1986.tb00838.x
Subject(s) - phagocytosis , biology , immune system , vacuole , macrophage , immunity , microbiology and biotechnology , parasite hosting , immunology , intracellular , chemotaxis , cytoplasm , in vitro , receptor , biochemistry , world wide web , computer science
Summary Trypanosoma musculi was killed by adherent peritoneal exudate cells which had the typical appearance of macrophages. Observations by light and electron microscopy showed that the trypanosomes were phagocytozed and killed intracellular^ within phagocytic vacuoles of mouse macrophages. Adherence, phagocytosis and killing of T. musculi required the presence of serum from mice immune to this parasite. Phagocytosis and killing of T. musculi was highly dependent on heat‐labile factors in immune mouse serum.