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Invasion of erythrocytes in vitro by Plasmodium falciparum can be inhibited by monoclonal antibody directed against an S antigen
Author(s) -
SAUL A.,
COOPER J.,
INGRAM L.,
ANDERS R. F.,
BROWN G. V.
Publication year - 1985
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1985.tb00102.x
Subject(s) - monoclonal antibody , plasmodium falciparum , biology , antigen , in vitro , antibody , virology , immunology , malaria , monoclonal , immune system , protozoa , microbiology and biotechnology , biochemistry
Summary A monoclonal antibody has been produced which binds to the heat stable S antigen present in the FCQ‐27/PNG isolate of Plasmodium falciparum . This monoclonal antibody also inhibits the invasion in vitro of erythrocytes by malarial merozoites thus demonstrating that the S antigens of Plasmodium falciparum may be a target of protective immune responses.