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Effects of anethole dithiolthione and 2(3)‐tert‐butyl‐4‐hydroxyanisole on schistosome granuloma formation
Author(s) -
FELDMAN GERALD M.,
NAPLES JEAN M.,
SEED JOHN L.,
BUEDING ERNEST
Publication year - 1985
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1985.tb00100.x
Subject(s) - granuloma , granuloma formation , superoxide , schistosoma mansoni , butylated hydroxyanisole , immunology , biology , scavenger , antioxidant , pharmacology , pathology , schistosomiasis , biochemistry , medicine , helminths , enzyme
Summary Administration of the antioxidants 2(3)‐tert‐butyl‐4‐hydroxyanisole (BHA) or 5‐( P ‐methoxyphenyl)‐3H‐1.2‐dithiol‐3‐thione (ADT) to female CD‐1 mice starting 4 weeks after infection with 70 cercariae of Schistosoma mansoni resulted in a decrease in the size of the inner fibrotic region of the hepatic granuloma. The cellular composition of the granuloma was not altered by treatment with these two compounds. The administration of the specific superoxide scavenger copper diisopropylsalicylate (CuDIPS) resulted in a similar decrease in granuloma size, suggesting a role of superoxide radicals in the granulomatous response.