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Susceptibility to coccidiosis: contrasting course of primary infections with Eimeria vermiformis in BALB/c and C57/BL/6 mice is based on immune responses
Author(s) -
ELAINE ROSE M.,
WAKELIN D.,
HESKETH PATRICIA
Publication year - 1985
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1985.tb00099.x
Subject(s) - coccidiosis , biology , immunosuppression , immune system , balb/c , immunology , immunity , cyclophosphamide , eimeria , parasite hosting , microbiology and biotechnology , medicine , pathology , chemotherapy , genetics , world wide web , computer science
Summary The effects of three immunosuppressive treatments‐whole body irradiation and injections of cortisone acetate or cyclophosphamide, on the course of primary infections with Eirneria verniformis were investigated in ‘resistant’ BALB/c and ‘susceptible’ CS7BL/6 mice. Immunosuppression (and the nude athymic mutation in BALB/c mice) resulted in increased reproduction of the parasite in both strains of mice, indicating some immunological control of primary infections. The effect was, however, very much more marked in the BALB/c mice, resulting in an alteration in the relative susceptibilities of the two strains. The findings are discussed and it is suggested that the basis for the differences observed in the course of infection in normal BALB/c and C57BL/6 mice lies in their immune responses to this parasite.