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Antigen specific and concanavaiin A‐induced lymphocyte blastogenesis responses during the course of Plasmodium berghei infection in rats
Author(s) -
RAYBOURNE R.,
DESOWITZ R. S.,
SANGHIRUN C.
Publication year - 1984
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1984.tb00814.x
Subject(s) - plasmodium berghei , biology , antigen , immunology , immune system , spleen , lymphocyte , plasmodium (life cycle) , immunity , parasite hosting , malaria , virology , world wide web , computer science
Summary Antigen specific and concanavaiin A (Con A)‐induced lymphocyte blastogenesis responses were monitored in the spleens of rats infected with Plasmodium berghei. Con A responses were depressed only at the time of peak parasitaemia. The antigen specific blastogenesis response was either not in evidence, or at a low level during the periods of patent or subpatent infection (up to 8 weeks after infection). Higher levels of blastogenesis were seen from 8 to 12 weeks after infection, which correlates with clearance of subpatent infection. Fractionation of immune spleen cell suspensions on nylon wool columns indicated that purified T cells did not respond to parasite antigen.