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Monoclonal antibody neutralizes the sporozoite stage of different Theileria parva stocks
Author(s) -
DOBBELAERE D.A.E.,
SPOONER P.R.,
BARRY W.C.,
IRVIN A.D.
Publication year - 1984
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1984.tb00808.x
Subject(s) - monoclonal antibody , biology , theileria parva , infectivity , virology , neutralization , antibody , antigen , protozoa , in vivo , in vitro , immunity , apicomplexa , blocking antibody , immunology , parasite hosting , microbiology and biotechnology , virus , immune system , protozoal disease , malaria , genetics , world wide web , computer science
Summary Monoclonal antibodies were raised against sporozoites of Theileria parva. One of these antibodies (MAbDi) neutralized the infectivity of sporozoites for lymphocytes in vitro and for cattle in vivo. Neutralization seemed to occur by blocking sporozoite entry into the cell. MAbDi neutralized sporozoites of four unrelated stocks of T. parva , indicating the presence of a common antigenic determinant which may be important in initiating protective immunity.