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Genetic control of susceptibility of mice to infection with E. histolytica
Author(s) -
GHADIRIAN E.,
KONGSHAVN P.A.L.
Publication year - 1984
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1984.tb00807.x
Subject(s) - biology , haplotype , axenic , entamoeba histolytica , inbred strain , immunology , major histocompatibility complex , gene , genetics , virology , microbiology and biotechnology , allele , bacteria
Summary Genetic susceptibility to Entamoeba histolytica infection in nine inbred strains and one outbred strain of mice was studied. The number of E. histolytica trophozoites in the ceca of the mice was examined 5 days after intracecal inoculation of axenic amoebae. C3H/HeCr, BALB/c, NZB/BIN, BIO.A, DBA/2 and C57BL/6 were susceptible whereas A/J, CE, DBA/1 and CD‐I mouse strains were relatively resistant. Examination of F 1 hybrid animals derived from susceptible B10.A and resistant A/J strains of mice showed that susceptibility was dominant over resistance. Segregation analysis of backcross and F2 progeny derived from the same progenitor strains is compatible with the hypothesis that susceptibility to E. histolytica infection in mice is controlled by a single, dominent gene which has been designated Enh. No association was found between the H‐2 haplotype and the trait of susceptibility to amoebiasis, indicating that the major histocompatibility complex does not play a major role in regulating the early phase of the response to infection with E. histolytica.