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Antibody‐dependent cellular cytotoxicity in chronic human Chagas disease
Author(s) -
VOLTARELLI J.C.,
FALCÅO R.P.,
SILVA J. SANTANA DA
Publication year - 1983
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1983.tb00753.x
Subject(s) - immunology , cytotoxicity , chagas disease , biology , antibody , antibody dependent cell mediated cytotoxicity , monoclonal antibody , in vitro , genetics
Summary Antibody‐dependent cellular cytotoxicity mediated by granulocytes (ADGC) or lymphocytes (ADLC) was assessed in 23 patients with chronic Chagas disease. The results of ADGC against T. cruzi were normal. ADLC against chicken erythrocytes was significantly reduced in patients as compared with normal controls. Possible causes of this abnormality were investigated.