Premium
Genetic association of murine susceptibility to Brugia malayi microfilaraemia
Author(s) -
FANNING MARY M.,
KAZURA J.W.
Publication year - 1983
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1983.tb00746.x
Subject(s) - brugia malayi , biology , congenic , parasitemia , immunology , antibody , lymphatic system , immune system , strain (injury) , gene , helminths , genetics , filariasis , plasmodium falciparum , anatomy , malaria
Summary The influence of host genetics on susceptibility of mice to Brugia malayi microfilariae and its possible mechanism were studied. There was a strain‐association for duration and peak level of microfilaraemia: CBA/CaJ, C3H/HeJ, DBA/1J, AuSs/J and A.Sw/Snhad a short duration (3–5 days) and low parasitemia (19–26 parasites/100 /il blood) compared to C57Br/cdJ, AKR/J, C57BL/6J, 129/J, BALB/cJ, DBA/2J, B10.D2/NSn, B10.D2/OSn and SJL/J(duration of 58–73 days, peak parasitaemia of 58–74 parasites/100 μl blood). Relative resistance to microfilariae was not related to the H‐2 complex as determined in studies of congenic C3H.B10 (H‐2 b ) and B10.H‐2 k mice and their background strains. This trait was inherited in a dominant fashion and involved a single or small number of genes. Serum anti‐microfilarial antibodies reached highest levels in strains with a long duration compared to those with a short duration of parasitaemia (geometric mean titres of 1:13450 vs 1:284). The distribution of 5l Cr‐labelled microfilariae among the livers, spleens, lungs and kidneys of a resistant (CBA/CaJ) and a susceptible (C57BL/6J) strain was similar. Transfer of immune lymphoid cells or sera between histocompatible (H‐2 k ) resistant CBA/CaJmice and susceptible C57Br/cdJ animals did not alter the duration of microfilaraemia.