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Immune depression in bovine trypanosomiasis: effects of acute and chronic Trypanosoma congolense and chronic Trypanosoma vivax infections on antibody response to Brucella abortus vaccine
Author(s) -
RURANGIRWA F.R.,
MUSOKE A.J.,
NANTULYA V.M.,
TABEL H.
Publication year - 1983
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1983.tb00743.x
Subject(s) - trypanosoma vivax , immunology , biology , vaccination , immune system , trypanosoma , trypanosomiasis , antibody , virology , antigen
Summary Cattle were vaccinated with Brucella abortus (S19) vaccine during acute (25 days) and chronic (25 weeks) Trypanosoma congolense and chronic Trypanosoma vivax (25 weeks) infections in order to determine the effect of such infections on the antibody response to the vaccine. It was found that the specific antibody responses of IgG 1 and IgG 2 sub‐classes were profoundly depressed (80%) in both the acute and chronic infections with T. congolense. Whereas IgM antibody response was also profoundly depressed (90%) in cattle with the acute infection, it was only 50% depressed in those with chronic infection. There was no depression of IgG 1 , IgG 2 , or IgM in cattle infected with T. vivax. These animals, however, had no detectable parasitaemia at the time of vaccination and thereafter. These results suggest that during acute infection with T. congolense depressive mechanisms could be acting on the afferent arm of the immune response, namely, antigen recognition and/or processing.