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Antilymphocyte autoantibody in lethal mouse malaria and its suppression by non‐lethal malaria
Author(s) -
SOUZA J.B. DE,
PLAYFAIR J.H.L.
Publication year - 1983
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1983.tb00742.x
Subject(s) - plasmodium yoelii , plasmodium berghei , autoantibody , biology , immunology , plasmodium chabaudi , cytotoxic t cell , malaria , parasitemia , antibody , plasmodium falciparum , biochemistry , in vitro
Summary Mice infected with lethal P. berghei or P. yoelii malaria develop anti‐lymphocyte autoantibodies less than a week after infection. The autoantibodies are IgM, T‐dependent and cytotoxic to a subpopulation of non‐T lymphocytes at 37°C in the presence of mouse or guinea‐pig complement. Non‐lethal P. yoelii and P. chabaudi do not induce these autoantibodies. X‐irradiated P. berghei parasites induce autoantibodies in normal mice but not in mice infected with non‐lethal P. yoelii suggesting an active suppressor mechanism in the non‐lethal infection.