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Effect of immunosuppressive or inflammatory agents on lymphatic dilatation in cats infected with Brugia pahangi
Author(s) -
DEAN GILLIAN S.,
PLAYFAIR J. H. L.,
DENHAM D. A.,
NOSCOE N.
Publication year - 1983
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1983.tb00729.x
Subject(s) - brugia pahangi , lymphatic system , cats , biology , immunology , lymphatic filariasis , anthelmintic , pathology , medicine , helminths , filariasis , ecology
Summary Cats infected with Brugia pahangi were immunosuppressed and the development of lymphatic pathology, as measured xeroradiographically by dilatation of the vessels, in these animals was compared with that of normally infected cats. Individual cats showed wide variations in response. Niridazole and antilymphocyte serum both reduced dilatation, niridazole being particularly effective in the early stages of infection. When silica, used as an inflammatory agent, was injected subcutaneously in conjunction with worm infection lymphatic dilatation developed, this being potentiated in degree and rate of development as compared with control animals. The possible role of a non‐filarial inflammatory response in the development of lymphatic dilatation is discussed.