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Site of expression of immunity to Naegleria fowled in immunized mice
Author(s) -
THONG Y. H.,
CARTER RF.,
FERRANTE A.,
ROWANKELLY B.
Publication year - 1983
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1983.tb00724.x
Subject(s) - naegleria fowleri , biology , amoeba (genus) , naegleria , microbiology and biotechnology , immunology , immunity , immune system , protozoa , meningoencephalitis
Summary An experiment was performed which confirmed a previous finding that mice are protected against Naegleria fowleri infection by immunization with amoeba‐free supernatant from amoeba cultures. Histological observations suggested that this protection is expressed mainly at the nasal mucosa and possibly results from the combined effects of polymorphonuclear leucocyte‐mediated killing of the amoeba and mechanical elimination of the organisms by extensive shedding of necrotic epithelium.