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Murine alloantigen acquisition by schistosomula of Schistosoma mansoni: Further evidence for the presence of K, D, and I region gene products on the tegumental surface
Author(s) -
GITTER B. D.,
DAMIAN R. T.
Publication year - 1982
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1982.tb00450.x
Subject(s) - schistosoma mansoni , biology , antigen , monoclonal antibody , gene , immunology , microbiology and biotechnology , trematoda , antibody , schistosomiasis , virology , genetics , helminths
Previous studies have demonstrated that shistosomula, recovered from the lungs of Schistosoma mansoni ‐infected mice, acquire H‐2K k and both I k and I s gene products. We confirmed and extended those observations by identifying several individual antigenic specificities mapping not only to H‐2K k and I‐A k (Sher, Hall & Vadas 1978), but to H‐2D k , I‐E k , H‐2K b , H‐2D b and I‐A b as well. Private H‐2 specificites 23 (H‐2K k ) and 32 (H‐2D k ) were identified on the tegumental surface of schistosomula isolated from C3H/Crgl mice (H‐2 k ). Larvae isolated from C57Bl/10Sn (B10) mice (H‐2 b ) were shown to acquire private specificities 33 and 2, which map to H‐2K b and H‐2D b respectively. I region associated (Ia) antigens coded for by genes mapping in the I‐A subregion (Ia. 2 and 3) and I‐E subregion (Ia. 7) were also acquired from C3H/Crgl mice. Schistosomula from B10 donors were shown to acquire Ia specificities 3 and 8, which are under I‐A subregion control. Evidence that monoclonal antibodies recognize H‐2 antigens on the larval surface is also demonstrated.