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Activation of the alternative pathway of bovine complement by Trypanosoma congolense
Author(s) -
TABEL H.
Publication year - 1982
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1982.tb00444.x
Subject(s) - alternative complement pathway , trypanosoma , biology , complement factor b , immunodiffusion , guinea pig , complement system , complement (music) , lysis , immunoelectrophoresis , radial immunodiffusion , classical complement pathway , trypanosomiasis , complement component 2 , microbiology and biotechnology , immunology , virology , biochemistry , antibody , genetics , complementation , gene , phenotype
Homogenates of Trypanosoma congolense and particulate and supernatant fractions thereof were, by two different techniques, shown to activate bovine complement via the alternative pathway. (1) All three preparations converted complement factor B bov to its split product B γ2 as demonstrated (a) qualitatively by immunoelectrophoresis and (b) quantitatively by radial immunodiffusion. (2) Lysis of guinea‐pig erythrocytes by bovine complement via the alternative pathway was inhibited by whole homogenates and particulate fractions of T. congolense organisms.