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The development of resistance in different inbred strains of mice to infection with Nematospiroides dubius
Author(s) -
PROWSE S.J.,
MITCHELL G.F.,
EY P. L.,
JENKIN C.R.
Publication year - 1979
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1979.tb00713.x
Subject(s) - biology , inbred strain , nematode , parasite hosting , larva , immunology , immunity , strain (injury) , virology , microbiology and biotechnology , immune system , genetics , gene , anatomy , ecology , world wide web , computer science , botany
Summary Infection by the intestinal nematode parasite Nematospiroides dubius was studied in seven different inbred mouse strains. Although there was some minor variation in the susceptibility of the different strains to a primary infection there were marked differences in their ability to develop resistance to infection following repeated exposure to infective larvae. The strains of mice which developed the best resistance also expelled adult worms arising from the previous infections. The adult worms resulting from a primary infection were slowly eliminated in two inbred strains studied whereas no loss occurred from outbred LACA mice. Although males and females of two strains, C3H/HeJand CBA/H were equally susceptible to a primary infection, the females developed better resistance than the male mice following two oral administrations of third stage larvae. Infected mice of every strain and both sexes contained high levels of IgG 1 , in the serum.