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Modulation by malaria infection of the induction of T lymphocyte‐dependent delayed‐type hypersensitivity and antibody formation to sheep erythrocytes in mice
Author(s) -
Michel Jc,
Lagrange Ph,
Bruno Hurtrel
Publication year - 1979
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1979.tb00712.x
Subject(s) - immunology , sensitization , malaria , biology , immunization , antibody , spleen , antigen , delayed hypersensitivity , immunity , lymphocyte , immune system
Summary A profound alteration of the inductive phase of delayed‐type hyper‐sensitivity and antibody formation to SRBC was found in malaria infected mice when sensitization with this antigen was performed intravenously at a critical time of the disease, but not after subcutaneous immunization, suggesting a major role for the spleen in the mechanism of immunodepression.