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Successful vaccination of cats against Brugia pahangi with larvae attenuated by irradiation with 10 krad cobalt 60
Author(s) -
OOTHUMAN P.,
DENHAM D.A.,
MCGREEVY P.B.,
NELSON G.S.,
ROGERS ROSEMARY
Publication year - 1979
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1979.tb00707.x
Subject(s) - brugia pahangi , vaccination , cats , biology , larva , inoculation , immunology , physiology , veterinary medicine , helminths , medicine , ecology
Summary Cats were vaccinated by the inoculation on 10 occasions of approximately 300 larvae of Brugia pahangi which had been irradiated with 10 krad cobalt 60. They were challenged on 3 occasions with normal larvae of either B. pahangi or B. patei. The vaccinated cats were resistant to challenge as demonstrated by either longer pre‐patent periods or failure to become microfilaraemic and by having fewer third, fourth or adult worms than normal controls. Although the vaccination procedure was unpractically heavy these results lend encouragement to the possibility of developing vaccines against filarial infections.