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The relevance to protection of three forms of delayed skin‐test response evoked by M. leprae and other mycobacteria in mice. Correlation with the classical work in the guinea‐pig
Author(s) -
ROOK G.A.W.,
STANFORD J.L.
Publication year - 1979
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1979.tb00699.x
Subject(s) - biology , guinea pig , skin test , immunology , relevance (law) , test (biology) , pathology , medicine , tuberculosis , ecology , endocrinology , political science , law
Summary The controversy surrounding the protective role of ‘delayed hyper‐sensitivity’ in tuberculous guinea‐pigs has never been resolved. This controversy has arisen because the term ‘delayed hypersensitivity’ is used indiscriminately to describe both a type of necrotic skin‐test reactivity which does not appear until 4–6 weeks after infection, and also non‐necrotic reactions which can be elicited within a few days. Responses closely analogous to both have been characterized in mice immunized with mycobacteria. Simple criteria are described which allow these responses to be distinguished from one another, and from the Jones‐Mote phenomenon. The relevance of each type to protection, susceptibility and immunopathology in leprosy, tuberculosis, leishmaniasis and listeriosis is discussed.